Corporations

• QSC AG, a German telecommunications and DSL provider
• QSC Audio Products, a global amplifier and loudspeaker manufacturer based in California
• Queens Surface Corporation, a former bus company in New York City
• Qatar Shipping Company, a ship company based in Qatar

Colleges

• Queen's School of Computing, a department of Queen's University in Kingston, Ontario, Canada
• Quirino State College, an institute of higher learning in Quirino, Philippines

Other uses

• Q.S.C. (Qatari Shareholding Company), a joint stock public or private shareholding company based in Qatar
• QSC, the IATA airport code for São Carlos Airport in Brazil
• QSC, acronym of Quartermaster Service Corps, a former component of the South African Army
• QSC in Australian legal documents refers to Supreme Court of Queensland
• QSC, a radiotelegraphic Q code meaning "are you a cargo vessel" when posed as a question
• qSc, a portion of the equation defining the pitching moment coefficient of an airfoil
• Quay Sailing Club, a sailing club in St. Germans, Cornwall, UK
• Queens Sports Club, a stadium in Bulawayo, Zimbabwe
• QSC&V (Quality, Service, Cleanliness & Value), a quality benchmark used by McDonald's Corporation
• QSC supercomputer (2004–2007), a supercomputer at Los Alamos National Laboratory which replaced the Blue Mountain Supercomputer